A panel of across the world well-known examine scientists and medical investigators brings jointly a various selection of without problems reproducible equipment for picking and quantifying a good number of particular genetic abnormalities linked to the wide spectrum of myeloid malignancies. Highlights comprise strategies for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and persistent eosinophilic leukemia, category of AML by way of DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative issues. as well as gene rearrangments, different prognostically appropriate molecular lesions similar to FLT3 mutations and WT-1 overexpression are coated.
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