By Charles J. Epstein
This booklet considers intimately the mechanisms of a massive human challenge. Chromosome imbalance impacts all phases of existence in methods starting from spontaneous abortion and retardation to behavioural difficulties and malignancy. Charles J. Epstein matters himself with how and why a selected chromosome imbalance produces a particular phenotype. His primary target is to attach chromosome aberrations with sensible abnormalities by way of gene expression, developmental and mobilephone biology, and metabolism. via his exam of this courting, we study extra approximately basic improvement and serve as. The ebook starts with an exploration of a number of human autosomal aneuploid phenotypes, with specific emphasis at the dating among genotype and phenotype. within the subsequent half, large theoretical concerns of the mechanisms which generate those phenotypes are tested just about reviews on guy and different organisms resembling micro organism and mice. Experimental ways to review the consequences of aneuploidy are offered subsequent with unique realization paid to the advance of version platforms for learning human aneuploidy.
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